A. Right, the tumor is composed of variable cell types with variable sizes; epidermoid, intermediate, clear cells and few mucous cells. The clear cell change is extensive in this case, however the presence of mucin filled cystic spaces lined partially by mucous cells (figure 4) is the key of the diagnosis of Mucoepidermoid carcinoma (MEC). CRTC1::MAML2 fusion is the most molecular event used in MEC diagnosis.
B. Wrong, HCCC characterized by nests and cords of clear cells and eosinophilic cells in a hyalinized or desmoplastic stroma. It is the main differential diagnosis for clear cell MEC, however mucin filled cystic spaces are not one of HCCC features.
C. Wrong, the presence of mucin filled cystic spaces lined partially by mucous cells in figure. 4 excludes this entity.
A. Right, the tumor is composed of variable cell types with variable sizes; epidermoid, intermediate, clear cells and few mucous cells. The clear cell change is extensive in this case, however the presence of mucin filled cystic spaces lined partially by mucous cells (figure 4) is the key of the diagnosis of Mucoepidermoid carcinoma (MEC). CRTC1::MAML2 fusion is the most molecular event used in MEC diagnosis.
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