A. Right, the lesion was formed of hyperplastic epithelium, which showed dysplastic changes in its whole thickness. Numerous mitotic figures, tear-drop rete ridges and bizarre looking cells were detected. However, the basement membrane was irregular with dysplastic epithelial cells evident in the underlying lamina propria. Intense inflammation in the underlying stroma was seen in relation to the areas of microinvasion. In this case, the history of Oral Lichen Planus was thought to be the main predisposing factor of this lesion.
Depth of invasion is the extent of cancer growth into the tissue beneath an epithelial surface. It could be measured from the adjacent intact basement membrane to the deepest point of invasion in the connective tissue. It’s limit in microinvasive SCC differs according to the site, however, all the previous studies on microinvasive oral SCC showed that it shouldn’t exceed 0.1 mm. There are no definite guidelines for the treatment of micro-invasive OSCC in the literature, however, deep excision of the lesion with 5-10 mm safety margins was suggested.
B. Wrong, the basement membrane was irregular with dysplastic epithelial cells evident in the underlying lamina propria. Intense inflammation in the underlying stroma was seen in relation to the areas of microinvasion.
C. Wrong, there were no the characteristic balloon cells nor intranuclear inclusion bodies. Moreover, in this case the epithelial dysplasia was clear which is not a feature in oral hairy leukoplakia.
A. Right, the lesion was formed of hyperplastic epithelium, which showed dysplastic changes in its whole thickness. Numerous mitotic figures, tear-drop rete ridges and bizarre looking cells were detected. However, the basement membrane was irregular with dysplastic epithelial cells evident in the underlying lamina propria. Intense inflammation in the underlying stroma was seen in relation to the areas of microinvasion. In this case, the history of Oral Lichen Planus was thought to be the main predisposing factor of this lesion.
Depth of invasion is the extent of cancer growth into the tissue beneath an epithelial surface. It could be measured from the adjacent intact basement membrane to the deepest point of invasion in the connective tissue. It’s limit in microinvasive SCC differs according to the site, however, all the previous studies on microinvasive oral SCC showed that it shouldn’t exceed 0.1 mm. There are no definite guidelines for the treatment of micro-invasive OSCC in the literature, however, deep excision of the lesion with 5-10 mm safety margins was suggested.
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