A. Wrong, there were no giant cells beneath the epithelium. all the giant cells were in the center of the lesion. Moreover, the collagen bundles were not well-formed and short; which is not consistent with giant cell fibroma.
B. Wrong, the lesion was well circumscribed and collagen bundles showed the shredded carrot appearance which is the opposite of desmoid-type fibromatosis; which is well-known for its long sweeping fascicles of spindle cells and collagen, as well as, for its infiltrative nature.
C. Right, the lesion is composed of haphazardly arranged spindle cells in a variably myxoid stroma. Coarse short collagen bundles (shredded carrot)
could be seen along with cells with comma-shaped or buckled nuclei. Some giant stellate cells could be found in the center of the lesion along with numerous mast cells (Figure 4). Neurofibroma is associated with NF1 tumor suppressor gene inactivation and its diagnosis could be confirmed with S100, CD34 and neurofilament protein.
C. Right, the lesion is composed of haphazardly arranged spindle cells in a variably myxoid stroma. Coarse short collagen bundles (shredded carrot)
could be seen along with cells with comma-shaped or buckled nuclei. Some giant stellate cells could be found in the center of the lesion along with numerous mast cells (Figure 4). Neurofibroma is associated with NF1 tumor suppressor gene inactivation and its diagnosis could be confirmed with S100, CD34 and neurofilament protein.
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